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Genes IV

Author: Benjamin Lewin
Publisher: Oxford ; New York Oxford University Press 1990
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

The purpose of this book is to account for the structure and function of genesin terms of extensive knowledge about both prokaryotes and eukaryotes. It explains what a gene is, how it is reproduced  Read more...

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Details

Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Benjamin Lewin
ISBN: 0198542674 9780198542674 0198542682 9780198542681
OCLC Number: 832165726
Description: xxii, 857 Seiten Illustrationen (some color) 29 cm
Contents: Introduction: Cells as macromolecular assemblies: cells obey the laws of physics and chemistry; cells are organized into compartments. Part 1 DNA as a store of information: genes are mutable units; DNA is the genetic material; the topology of nucleic acids; isolating the gene. Part 2 Translation - expressing genes as proteins: the assembly line for protein synthesis; transfer RNA - the translational adaptor; the ribosome translation factory; the messenger RNA template; the apparatus for protein localization. Part 3 Transcription - control of prokaryotic genes: control at initiation - RNA polymerase-promoter interactions; a panoply of operons - the lactose paradigm and others; posttranscriptional feedback and control; control at termination - attenuation and antitermination; lytic cascades and lysogenic repression. Part 4 Perpetuation of DNA: the replicon - unit of replication; the apparatus for DNA replication; systems that safeguard DNA. Part 5 The packaging of DNA: about genomes and chromosomes; organization of nucleosomes in chromatin; the nature of active chromatin. Part 6 Constitution of the eukaryotic genome: the extraordinary power of DNA technology; a continuum of sequences includes structural genes; the organization of interrupted genes; structural genes evolve in families; genomes sequestered in organelles; organization of simple sequence DNA. Part 7 Reaching maturity - eukaryotic RNA synthesis and processing: building the transcription complex; mechanisms of RNA splicing; control of RNA processing. Part 8 The dynamic genome - DNA in flux: recombination and other topological manipulations; transposons that mobilize via DNA; retroviruses and retroposons; engineering changes in the genome. Part 9 Genes in development: generation of immune diversity involves reorganization of the genome; changing gene organization from within and without; gene regulation in development - cascades and gradients; oncogenes - aberrant gene expression and cancer. Epilogue: landmark shifts in perspectives.
Other Titles: Genes four
Responsibility: Benjamin Lewin
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