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The Dynamic genome : Barbara McClintock's ideas in the century of genetics

Author: Nina V Fedoroff; David Botstein
Publisher: [Cold Spring Harbor, N.Y.] : Cold Spring Harbor Laboratory Press, 1992.
Edition/Format:   eBook : Document : Biography : EnglishView all editions and formats
Summary:
"Barbara McClintock was born in 1902, within a few years of the rediscovery of Mendel's Laws. Her life, discoveries, and insights span the history of genetic science in this century." "In the 1920s, she became a dominant figure in the group that flourished at Cornell University under R.A. Emerson and made remarkable technical conceptual advances in maize cytogenetics. These studies continued at the California
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Details

Genre/Form: Biography
Biographies
Additional Physical Format: Print version:
Dynamic genome.
[Cold Spring Harbor, N.Y.] : Cold Spring Harbor Laboratory Press, 1992
(DLC) 92010074
(OCoLC)25632448
Named Person: Barbara McClintock; Barbara McClintock; Barbara McClintock; Barbara McClintock; Barbara McClintock
Material Type: Biography, Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Nina V Fedoroff; David Botstein
OCLC Number: 644020726
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (vii, 422 pages) : illustrations
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Recollections of Barbara McClintock's Cornell years / H.B. Creighton --
Barbara McClintock : reminiscences / C. Burnham --
Barbara McClintock : recollections of a graduate student / H.V. Crouse --
Neurospora chromosomes / D.D. Perkins --
The early years of maize genetics / M.M. Rhoades --
Insertion by phages and transposons / A. Campbell --
Cold Spring Harbor 1944-1955 : a minimemoir / E.M. Witkin --
Annals of mobile DNA elements in drosophila : the impact of influence of Barbara McClintock / M. Green --
The mutable waxy and bronzel alleles of maize / O.E. Nelson --
Remembrances of Barbara McClintock / L.L. Miller, Jr. --
The nucleolar-organizing element / J.G. Gall --
Do some "parasitic" DNA elements earn an honest living? / M.L. Pardue --
The plural of heterochromatin / C.D. Laird --
A tapestry of transposition / A.M. Skalka. Kernels and colonies : the challenge of pattern / J.A. Shapiro --
Phage mu : an early prokaryotic controlling element / M.M. Howe --
McClintock (1933) : implications for meiotic chromosome pairing / N. Kleckner --
Twenty-five years of transposable element research in Koln / H. Saedler, P. Starlinger --
Obsession with sequences / N.D.F. Grindley --
The revenge of the Mayans / G. Albrecht-Buehler --
"Please come to my laboratory for better coffee, fresh orange juice ... / B.M. Alberts --
Transposable elements (Ty) in yeast / G.R. Fink --
Controlling elements, mutable alleles, and mating-type interconversion / I. Herskowitz --
Thinking about programmed genome rearrangements in a genome static state of mind / J.N. Strathern --
The role of McClintock's controlling element concept in the story of yeast mating-type switching / A.J.S. Klar --
From bacterial flagella to homeodomains / M.I. Simon --
Discovery of Tc1 in the nematode, caenorhabditis elegans / P. Anderson, S.W. Emmons, D.C. Moerman --
Broken chromosomes and telomeres / E.H. Blackburn --
Maize transposable elements : a story in four parts / N.V. Fedoroff.
Responsibility: edited by Nina Fedoroff, David Botstein.

Abstract:

"Barbara McClintock was born in 1902, within a few years of the rediscovery of Mendel's Laws. Her life, discoveries, and insights span the history of genetic science in this century." "In the 1920s, she became a dominant figure in the group that flourished at Cornell University under R.A. Emerson and made remarkable technical conceptual advances in maize cytogenetics. These studies continued at the California Institute of Technology, in Freiburg, Germany, and at the University of Missouri. In 1942, she joined the staff of the Carnegie Institution of Washington at Cold Spring Harbor, New York, where she remains a Distinguished Service Member." "McClintock's unique ability to discern relationships between the behavior of chromosomes and the properties of the whole organism earned her early recognition. She was elected to the National Academy of Sciences in 1944 and to the presidency of the Genetics Society of America in 1945. Had she done no more, McClintock would have become a major figure in the history of genetics." "But at Cold Spring Harbor, she began the studies on the consequence of dicentric chromosome formation and breakage that led her to the discovery of genetic elements capable moving within the genome and controlling expression of other genes. Although McClintock was universally respected and admired, the first reaction to these findings was often uncomprehending or indifferent, even dismissive. In due course, however, the generality of mobile genetic elements and the concept of a dynamic genome were understood and widely accepted, culminating in the award to McClintock of an unshared Nobel prize in 1983."

"As Barbara's 90th birthday approached, some of her many friends and colleagues were invited to write essays for the occasion. This book contains a kaleidoscope of contributions, many by those who discovered transposition in other organisms. Their essays give a remarkable account of the scientific legacy of one of the century's greatest geneticists."--Jacket.

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